Circulating immunoglobulin-secreting cells are heterogeneous in their expression of maturation markers and homing receptors
نویسندگان
چکیده
منابع مشابه
Circulating immunoglobulin-secreting cells in patients with plasma cell dyscrasia.
Immunoglobulin-secreting cells (ISC) in peripheral blood mononuclear cells (PBM) isolated from patients with plasma cell dyscrasia of various stages were studied using reverse hemolytic plaque assay. Normal healthy individuals contained 35 +/- 16 ISC/10(5) PBM. Aleukemic or subleukemic patients with overt myeloma contained 825 +/- 713 ISC, whereas leukemic patients contained 12,675 +/- 2520 ISC...
متن کاملCirculating Immunoglobulin - Secreting Cells in Patients With Plasma Cell
Immunoglobulin-secreting cells (ISC) in peripheral blood mononuclear cells (PBM) isolated from patients with plasma cell dyscrasia of various stages were studied using reverse hemolytic plaque assay. Normal healthy individuals contained 35 ± 16 ISC/105 PBM. Aleukemic or subleukemic patients with overt myeloma contained 825 ± 713 ISC. whereas leukemic patients contained 1 2,675 ± 2520 ISC. Patie...
متن کاملSplenic immunoglobulin-secreting cells and their regulation in autoimmune mice
We have investigated in vitro the magnitude, nature, and regulation of spontaneous and mitogen-induced Ig secretion by splenic lymphocytes from several autoimmune murine strains (NZB, NZB X W, MRL/l BXSB) and appropriate, normal mice. All autoimmune strains had increased numbers of mature splenic B lymphocytes, which secreted and/or contained Ig, compared to age-matched normal strains. In NZB a...
متن کاملImmunoglobulin Secreting Cells
(P < 0.02). The mean number of IgA secreting cells in bronchial lavage fluids was 633 per million lymphocytes as compared to 100 per million lymphocytes in peripheral blood (P < 0.005). Thus, compared to peripheral blood, cells from the lavage fluids were relatively enriched for both IgG and IgA secreting cells. However, IgA secreting cells were the major class of immunoglobulin secreting cells...
متن کاملHoming Receptors on Human Circulating Antibody-forming Cells
Expression of the adhesion molecules CD44, L-selectin (CD62L), and integrin a 4 b 7 by antibody-secreting cells (ASC) was examined in human volunteers after oral, rectal, intranasal, or systemic immunization with cholera toxin B subunit. Almost all blood ASC, irrespective of immunization route, isotype (IgG and IgA), and immunogen, expressed CD44. On the other hand, marked differences were obse...
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ژورنال
عنوان ژورنال: Clinical and Experimental Immunology
سال: 1996
ISSN: 0009-9104,1365-2249
DOI: 10.1046/j.1365-2249.1996.47751.x